Lecture 7

Question 1

oncotype DX

Answer 1

a test that predicts how likely breast cancer is to spread to somewhere else in the body (secondary breast cancer) within 10 years of diagnosis

Question 2

standard breast cancer DX

Answer 2

clinical and histopathological data

Question 3

molecular breast cancer dx

Answer 3

intrinsic gene expression

Question 4

quiescence

Answer 4

temporary termination of cell division stalled at checkpoint or G0
- defined as G0, or stopping at any of the checkpoints

Question 5

senescence

Answer 5

permanent termination of cell division
- ha reached the haflick limit ehich is roughly 50 cell divisions limited by chromosomal telomeres

Question 6

mitotic crises

Answer 6

cell death during mitosis
- due to DNA damage

Question 7

Necrosis

Answer 7

traumatic cells death
- passive process due to injury

Question 8

Programmed cell death

Answer 8

• require ATP and are organized

Question 9

examples of programmed cell death

Answer 9

apoptosis
anoikis
effereocytosis, autography,etc

Question 10

extrinsic apoptosis key factor

Answer 10

TNF receptor (tumor necrosis factor)

Question 11

intrinsic apoptosis key factor

Answer 11

DNA damage
- or hypoxnia and cell cycle abnormalities