lecture 3: viral origins of cancer

Question 1

oncovirues

Answer 1

virus associated with cancer

Question 2

oncoviruses accounts for __of all cancer and __ of cancer deaths

Answer 2

16%, 10%

Question 3

human papilloma virus

Answer 3

non lytic , 200 types, only a few oncoviruses

Question 4

vaccine for non-lytic HPV

Answer 4

gardasil 9

Question 5

cancers from HPV

Answer 5

cervical, throat, hematological cancer

Question 6

HPV protein expression

Answer 6

E6/E7 –> inactivate p53 and pRb

Question 7

Epstein-Barr Virus

Answer 7

nasopharyngeal cancers and lymphoma
lytic
200k cancers per year worldwide

Question 8

Hepatitis B & C

Answer 8

liver cancer
causes acute heapititis

Question 9

explain why cancers caused by virus might be eradicated before chemically caused cancer

Answer 9

• has to have a host in order to propagate
• if you can block what causes it then you can end if for good
• herd immunity

Question 10

how to determine if a malignant mass originated from a retroviral infection

Answer 10

• use reverse transcriptase
• in general, you can sequence and look for sequences that are not of human origin or RNA that are not of human origin
• can potentially look at the function and the pproteins that arise from this