PRACTICAL: Liver-pancreas pathology Flashcards
What is labelled in this image?
LP = limiting plate (junction b/w portal triad and liver) PV = portal vein BD = bile duct HA = hepatic artery LV = lymphatic vessel
What are microscopic findings that are diagnostic for PSS? 2
Arterioles increase in number Portal areas don’t contain a vein
What causes a liver to look like this? What other signs might be apparent?
(nutmeg liver) Right-sided cardiac failure causing chronic passive venous congestion. OTHER SIGNS: congestion of other abdominal organs and ascites
What are the dark bits of a nutmeg liver?
congestion of periacinar regions in and around the central veins, Due to relative blood stasisi and inadquate nutrition of liver cells around the central vein so become hypoxic and over time the cells die and disappear. Sinusoids then dilate and fill with blood
What are the pale areas of a nutmeg liver?
Fatty change in mid-zonal and periportal areas, due to inadequate nutrition of cells (i.e. same cause as for the dark regions of nutmeg liver)
What is this called?
Fatty liver
How can fat vacuoles be demonstrated in hepatocytes?
fresh frozen tissue sections must be used in frozen tissue, the lipid can be visualised by using special stains (Oil Red O = red stain. Sudan black = black stain)
What does this show?
Small light pale foci indicative of necrosis in the hepatic parenchyma. This happens in acute necrosis. Microscopically, the necrotic areas are infiltrated by a few neutrophils. Rare hepatocytes at the margin of the necrosis contain intranuclear inclusion bodies.
What does this show?
immunoperoxidase staining of viral Ag (brown) = EHV-1
What does this show?
hepatic abscessation (microscopic image from lesion edge shows many neutrophils which are indicative of abscessation)
What predisposes hepatic abscessation?
ADULT GOATS = ruminal acidosis (bacteria enter circulation across rumen wall which lead to development of liver abscesses KID = umbilical infection (omphalophlebitis)
Suggest a primary hepatic tumour
a benign hepatoma (usually a single large mass)
Suggest a secondary hepatic tumour
e.g. metastatic haemangiosarcoma (primary tumour commonly found in spleen, heart or SC tissues, less commonly found in the liver, usually metastasizes here)
