Icterus/HE in small animals Flashcards
In what form in newly formed unconjugated bilirubin?
insoluble in water, bound to albumin, dissociates from this before entering liver cell
What happens to bilirubin in the liver cell?
Conjugation with glucoronic acid making it water-soluble for excretion in urine (rate limiting step in hepatocyte)
What do bacteria in the lower urinary tract do?
convert bilirubin into urobilinogen –> enterohepatic circulation
Define pre-hepatic icterus
conjugation and uptake of bilirubin into liver overwhelmed
Define hepatic icterus
uptake, conjugation and excretion of bilirubin in hepatocytes overwhelmed
Define post-hepatic icterus
conjugation, excretion and uptake back into liver overwhelmed
What signs might show clinical signs of icterus? 4
- GIT
- neurologic
- renal/urinary
- haematologic
GIT signs 4
- vomiting and diarrhoea (common)
- acholic faeces (i.e. white)
- melaena
- ascites
Neuo signs of HE 6
- personality change
- ptyalism (drooling, cats)
- head pressing
- disorientation
- seizures
- stupor
Renal signs 6
Pu/PD (insufficient urea to concentrate) pollakiuria stranguria dysuria bilirubinuria
Define pollakiuria
excessively high daytime frequency of urination
Define stranguria
slow, painful urination caused by mm spasms of the urethra and bladder
Define dysuria
painful micturition
Haematologic signs 6
- yellow animal
- pale MM
- anaemia from GIT haemorrhage
- anaemia of chronic disease
- coagulation disorder
- haemolysis
DDx for pre-hepatic icterus
Haemolysis (IMHA, babesia infection, toxins - onions, lead , copper)