PPIs 2 Flashcards
OTC PPI age
18 and over
how long can you use nexium for
14 caps - 14 days
contact doctor if not free from symptoms after this period
esomeprazole
GSL
omeprazole GSL
- pack sizes
- strength
- indication
- duration
- age
Omeprazole 10mg and 20mg tablets are available as GSL medicines for the short-term relief of reflux-like symptoms in adults over 18 years, at a maximum daily dose of 20mg, to be taken for maximum of 4 weeks and a maximum pack size of 28 tablets (10mg) and 14 tablets (20mg).
PPI interaction with citalopram
increases exposure of escitalopram, citalopram
monitor and adjust dose
PPIs interact with this immunosuppressant (hint: high risk drug). what is it and what is the interaction?
MTX
they decrease the clearance of Methotrexate (high-dose). Therefore risk of TOXICITY
Manufacturer advises use with caution or avoid.
A patient, 44 yrs old, would like to buy some pyrocalm tabs (20mg omeprazole) or nexium (esomeprazole) because they are suffering from some heartburn and indigestion. However you refuse the sale because they are on a particular medication. What is it and what is the interaction
hint antiplatelet
predicted to decrease the efficacy of Clopidogrel. Manufacturer advises avoid.
A patient, 70, presents with a prescription for omeprazole 20mg OD for 8 weeks for the treatment of an NSAID induced ulcer.
They take no other medications. You advice them that they must tell their doctor to assess them for osteoporosis because they will be at a high risk of fractures now that they are taking them. True or false??
False
Can increase the risk of fractures (particularly when used at high doses for over a year in the elderly)!!
This patient is only on it short term, 8 weeks at standard dose. so the advice is inappropriate
omeprazole GR caps label
Swallow this medicine whole. Do not chew or crush
esomeprazole GR caps label
nothing!!!
lansoprazole label
orodisp tab + caps
Do not take indigestion remedies 2 hours before or after you take this medicine
Take 30 to 60 minutes before food
Swallow this medicine whole. Do not chew or crush (this is additioanl for caps)
omeprazole and esomeprazole interacts with these antidepressants
Omeprazole is predicted to increase the exposure to Escitalopram, citalopram. Manufacturer advises use with caution and adjust dose.
all PPIs have an important interaction with this high risk drug
Omeprazole decreases the clearance of Methotrexate (high-dose). Manufacturer advises use with caution or avoid.
omeprazole and esomeprazole interact with this antiplatelet
Omeprazole is predicted to decrease the efficacy of Clopidogrel. Manufacturer advises avoid.
use lansoprazole instead
omeprazole, esomeprazole, lansoprazole + keto/itraconazole
Omeprazole decreases the absorption of Ketoconazole. Manufacturer advises administer ketoconazole with an acidic beverage.
PPIs and contraceptive interaction
PPIs might decrease the efficacy of Ulipristal for EHC
