H2 receptor antagonists Flashcards
cautions for all h2ra
they may mask the signs and symptoms of gastric cancer
particular care needed in pt presenting with alarm features - rule of gastric malignancy before treatment
pt who regularly takes famotidine has been prescribed ketoconazole/itraconazole. what would you advise
Famotidine is predicted to decrease the absorption of Ketoconazole. Manufacturer advises administer Ketoconazole with an acidic beverage.
true or false - they can affect EHC
true. they can decrease the efficacy of ulipristal
7 common SE for all h2ra include
Constipation; diarrhoea; dizziness; fatigue; headache; myalgia; skin reactions
can you use in preg or BF
avoid
cimetidine interaction with coumarins
acenocoumarol, warfarin, pheninidone
it increases the AC effect.
cimetidine interacts with this high risk drug commonly used in asthma. what is the interaction
Cimetidine increases the concentration of Aminophylline. Manufacturer advises adjust dose.
cimetidine and 3Ps1C, fosphenytoin
Cimetidine transiently increases the concentration of Carbamazepine. Manufacturer advises monitor concentration and adjust dose.
cimetidine and citalopram, escitalopram
Cimetidine slightly increases the exposure to Citalopram. Manufacturer advises adjust dose.
cimetidine and diltiazem
Cimetidine slightly increases the exposure to Diltiazem. Manufacturer advises monitor and adjust dose.
cimetidine and TCAs - amitrip, dosulepin, dose-in etc
Cimetidine increases the exposure to Dosulepin. Manufacturer makes no recommendation.
cimetidine and erythromycin
Cimetidine slightly increases the exposure to Erythromycin. Manufacturer makes no recommendation.
cimetidine interacts with this opioid used for severe pain
Cimetidine might increase the exposure to Fentanyl. Manufacturer advises monitor and adjust dose.
amidarone, flecainide, lidocaine, propafenone and cimetidine
Cimetidine slightly increases the exposure to Flecainide. Manufacturer advises monitor and adjust dose.
cimetidine interact with itraconazole , ketoconazole
Cimetidine is predicted to decrease the absorption of Itraconazole. Manufacturer advises administer Itraconazole capsules with an acidic beverage.
cimetidine interaction with nifedipine
cimetidine moderately increases the exposure to Nifedipine. Manufacturer advises monitor and adjust dose.
cimetidine interaction with quinine, chloroquine, hydroxyquinine
Cimetidine slightly increases the exposure to Quinine. Manufacturer makes no recommendation.
if cimetidine is used in HI, there is increased risk of what side effect
confusion
due to safety concerns about a contaminant, all formulations of this h2ra are currently unavailable in the UK
no new pt to be initiated on treatment with it!
ranitidine
does cimetidine interact with antidepressants e.g. mirtazapine, paroxetine, sertraline
yes increases exposure
