misoprostol

Question 1

peptic ulcer disease - when is it used

Answer 1

In patients with previous ulceration, for whom NSAID continuation is necessary, or those at high risk of gastro-intestinal side effects, consider a COX2 inhibitor instead of a standard NSAID.

Gastro-protection with acid suppression therapy should always be co-prescribed. A PPI is the preferred choice for gastro-protection; other options include a H2RA or misoprostol, but the side effects of misoprostol limit its use.

Question 2

MOA

Answer 2

Misoprostol is a synthetic prostaglandin analogue that has antisecretory and protective properties, promoting healing of gastric and duodenal ulcers. It also acts as a potent uterine stimulant.

Question 3

other indication, not GI

Answer 3

induction of labour, termination of pregnancy

Question 4

brand for GI use

Answer 4

cytotec

Question 5

SE

Answer 5

Chills; constipation; diarrhoea; dizziness; fever; flatulence; gastrointestinal discomfort; headache; nausea; skin reactions; vomiting