PPA Flashcards
What are three types of PPA?
- Non fluent variant
- Semantic variant
- Logopenic varient
Non-fluent variant diagnostic criteria
At least 1 of:
1. Agrammatism
2. Apraxia of speech (halting, effortful production)
At least 2 of:
1. Impaired comprehension of syntactically complex sentences
2. Spared object knowledge
3. Spared single word comprehension
Non fluent variant pathology/category
Frontotemporal dementia
Tau-opathy
Non fluent variant imaging findings
Left posterior fronto-insular atrophy
Semantic variant diagnostic criteria
Both core features:
1. Impaired single word comprehension
2. Impaired confrontation naming
At least 3 of:
1. Impaired object knowledge
2. Surface dyslexia or dysgraphia
3. Spared repetition
4. Spared speech production
Semantic variant pathology
Frontotemporal
TDP-43
Semantic variant brain area
Asymmetric bilateral anterior temporal atrophy
L to R
Logopenic variant diagnostic criteria
Both of:
1. Impaired single-word retrieval (spont speech and naming)
2. Impaired repetition of sentences and phrases
At least 3 of:
1. Speech (phonologic) errors in spontaneous speech and naming
2. Spared single word comprehension and object knowledge
3. Spared motor speech
4. Absence of frank agrammatism
Logopenic variant pathology
Alzheimer’s
Logopenic variant area of brain
Left posterior temporoparietal or Left perisylvian
Diagnostic criteria for PPA general
Inclusion:
1. Most prominent feature is difficulty with language
2. Deficits are principal cause of impaired ADLs
3. Aphasia most prominent deficit at symptom onset and in early phases of disease
Exclusion:
1. Better accounted for by other ND or medical disorder
2. Better accounted for by psychiatric disorder
3. Prominent initial episodic memory, visual memory, visuoperceptual impairments
4. Prominent initial behavioural disturbance
