PP 11 Basic Molecular Pathology Flashcards
What is NSCLC?
Non-small cell lung carcinoma
Any type of epithelial lung cancer other than small cell cancer
What oncogenes are associated with lung adenocarcinomas?
EGFR - epidermal growth factor receptor
ALK - anaplastic lymphoma kinase
ROS1
KRAS
MET - hepatocytes GFR
RET
Her2 - human epidermal GFR 2
What is EGFR?
Epidermal growth factor receptors
Oncogene associated with lung adenocarcinomas
What is ALK?
Anaplastic lymphoma kinase
Oncogene associated with lung adenocarcinoma
What is Her2?
Human epidermal GFR 2
Oncogene associated with lung adenocarcinoma
How to get a biopsy from a central lung issue?
Bronchoscope
When is PDL1 tumour marker requested?
In lung squamous cell carcinomas
What lung adenocarcinoma markers tend to be in non smokers?
EGFR
ALK
Ros1
What lung adenocarcinoma marker tends to be in smokers?
Kras
What population have most mutations of EGFR?
Asian
What is EGFR?
Where is it seen?
How is it detected?
Most frequent mutation
Treatment
Epidermal growth factor receptor
Oncogene - transmembrane RTK
Lung adenocarcinomas marker
Detected with PCR
Deletion in exon 19 of Ch7
Treatment - anti EGFR TKI drugs gefitinib
What is RTK?
Receptor tyrosine kinase
Who is ALK lung molecular marker commonly seen in?
Young non smokers
What is ALK?
Where is it seen?
How is it detected?
Most commonly seen in
Treatment
Anaplastic lymphoma kinase
Oncogene - RTK insulin receptor
Lung adenocarcinoma marker
Detected with PCR
Young non smoker
Treatment - ATP kinase inhibitors crizotinib
Treatment of EGFR mutation
Anti EGFR TKI drugs
e.g. gefitinib