Powerpoint - Pharmacokinetics & Pharmacodynamics Review Flashcards
The effect of the drug in the body is (does it raise bld sugar levels or b/p):
pharmacodynamics
The effect of the body on the drug is (how it is eliminated or processed in the body):
pharmacokinetics
What are the 5 pharmocokinetic processes that we are concerned about with any drug?
1) liberation
2) absorption
3) distribution
4) metabolism
5) excretion
What is the fraction of a drug which is absorbed into the bloodstream?
Bioavailability
The extent to which a drug is distributed in the body
Volume of distribution
Warfarin has a ___ distribution and digoxin has a ___ distribution (outside of bloodstream)
small, large
How quickly a drug is eliminated from the body
half-life
The short the half-life, the more ___ it is eliminated. The longer the half-life, the ___ it takes to be eliminated.
quickly, longer
Occurs when the amt of drug going into the body exceeds the amt being eliminated, so it begins to accumulate in the bld stream
drug accumulation
The rate of removal of a drug from a theoretical volume
clearance
The higher the clearance, the more ___ the drug is being eliminated. The lower the clearance, the ___ it takes to be eliminated.
quickly, longer
The amount coming in is equal to the amount going out
steady state
Not all drug effects are ___-dependent, but most drug effects are ___-dependent. (The greater the ___, the greater effect you will see)
concentration, dose
Therapeutic and toxic effects of a drug often overlap, such as ___.
chemotherapy
The bigger the dose does not always mean the bigger the effect. This is known as the ___ effect. For example, increasing the dose of morphine will cause a ___ in respirations.
ceiling, decrease
