Postsynaptic Mechanisms Flashcards
Metabotropic receptors is a process of ___
Amplification
2 types of major proteins for metabotropic receptors:
_____ -coupled receptors
Receptor ____ kinase
G protein
Tyrosine
When a metabotropic receptors binding site is bound by a neurotransmitter, the receptor undergoes a ___ change that either directly or indirectly activates an ___
Conformational
Enzyme
The metabotropic activated enzyme is the ___ effector and converts a bioactive ___ known as a ____
Primary effector
Metabolite
Second messenger
G-protein =
Guanine-nucleotide
GTP + GTPase=> ____ similar to ATP
Energy
The most common category of metabotropic receptors in the nervous system are ___ coupled receptors
G-protein coupled
The G-protein coupled receptor B1-andrenergic receptor has 2 ____ residues which are the sites for phosphorylation involved with ___ the receptor
Serine
Inactivating
G-protein trimers are complex that can ___ activity of certain ionic channels (DIRECTLY/ INDIRECTLY)
Regulate
Directly
3 Most common messenger pathways:
cAMP pathway
IP3/ DAG
Arachidonic Acid
cAMP system pathway:
____ —> B-andrenergic pathway-> G protein + ____ cyclase—> ___ and cAMP-dependent kinase
Norepinephrine
Adenylyl cyclase
cAMP
IP3/DAG pathway:
ACh —> ___ receptor —> G-protein + ____—>IP3+ DAG—> PKC and ___ release
Muscarinic ACh
PLC — phospholipase C
Ca release
Arachidonic acid system:
___—->histamine receptor—> G protein + ___ —-> arachidonic acid —> ____(3 possible compounds)
Histamine PLA2–phospholipase 2 5-lipoxygenase 12-lipoxygenase Cyclooxygenase
Cyclic AMP reaction is catalyzed by:
Adenylyl cyclase
Cyclic AMP activates:
PKA
Protein Kinase A
