Posterior Pituitary Issues

Question 1

what are the precursors of ADH and oxytocin in the post pit

Answer 1

propressophysin

proopressophysin

Question 2

what is action of oxytocin?

Answer 2

stim of uterine muscle contraciton and stim of myoepithelial cells of mammary alveoli

Question 3

what is main player in regulation of ADH release?

Answer 3

serum osmolality

Question 4

if serum osmolality is high, do you want less or more ADH?

Answer 4

MORE

Question 5

if volume is low do you want more or less ADH?

Answer 5

MORE

Question 6

what renal thing leads to more ADH?

Answer 6

ATII

Question 7

what is difference in central and nephrogenic DI?

Answer 7

central is issue with ADH release from post pit and nephrogenic is issue with kidney response to ADH

Question 8

what can cause central DI?

Answer 8

trauma, malignancy, sarcoid, surgical issues

Question 9

what can cause nephrogenic DI?

Answer 9

genetic, hypercalcemia
hypokalemia
lithium amphotericin B gentamicin
cisplatin

Question 10

what drugs cause nephrgenic DI?

Answer 10

lithium
ampho B
gentamicin
cisplatin

Question 11

will urine osmolality go up or down with vasopressin administration in central DI?

Answer 11

will go up

Question 12

will urine osmolality go up or down with vasopressin administration in nephrogenic DI?

Answer 12

will stay the same

Question 13

what is first line treatment for central DI?

Answer 13

water

Question 14

what is second line treatment for central DI?

Answer 14

DDAVP

Question 15

what are two drugs to treat nephrogenic DI?

Answer 15

HCTZ and amilioride

Question 16

what four groups of things can cause SIADH?

Answer 16

CNS disease
diseses of lung and mediastinum
ectopic AVP production
drugs

Question 17

will urine sodium be up or down in SIADH?

Answer 17

up

Question 18

will serum osmolality be high or low in SIADH?

Answer 18

low

Question 19

will sodium be high or low in SIADH?

Answer 19

low

Question 20

will there be hypotension or hypertension in SIADH?

Answer 20

no

Question 21

if you get neurologic symptoms in SIADH, what do you use to treat? what should you def not use?

Answer 21

hypertonic saline treats and isotonic saline is contraindicated