Post Absorptive State Flashcards
Post absorptive state occurs when
Late morning, late afternoon and through the night
What is the main aim of metabolic processes during the post absorptive state?
Maintain the blood glucose level in the normal range
Can fatty acids cross the blood brain barrier?
No
What is the major hormone released in the post absorptive state?
Glucagon
What other hormones increase glucose levels?
Adrenaline
Cortisol
Growth
Thyroid
Glucagon primarily targets the…
Liver
Lack of insulin leads to what
Triglyceride release
Sympathetic nervous system (SNS)
1- Hypothalamus detects low blood glucose
2- SNS nerves
3- Adrenaline and non adrenaline are released from the adrenal medulla
4- Stimulates glycogen breakdown to glucose
5- Stimulates lipolysis triglycerides to free fatty acids and glycerol
When is cortisol highest?
In the morning after fasting overnight
What is the function of adrenocorticotrophic hormone?
Controls the release of cortisol
What are the effects of cortisol?
Increases blood glucose levels
Dampens inflammatory response
Targets several body tissues to increase available energy
Decrease in TAGs breakdown
Type I diabetes
No insulin
Glucose is unavailable to enter those energy storage body cells
Oxaloacetate becomes depleted and acetyl coa is unable to enter krebs cycle
FA and AA unable to be metabolised cause lack ATP
Type II diabetes
Caused by insulin resistance
Energy cells do not want more energy so attempt to block glucose entry
