Polyps Flashcards
Colonic polyps structures
- flat
- sessile
- pedunculated
pedunculated means?
pedunculated (on a stalk)
4 HISTOLOGIC TYPEs of Colonic polyps
Hyperplastic
Hamartomatous
Adenomatous
Serrated
Neoplastic Colonic polyps
Adenomatous
polyps Generally smaller and majority located in rectosigmoid area.
Hyperplastic
Hamartomatous
Associated with Peutz-Jeghers syndrome and juvenile polyposis.
Hamartomatous
Growths of normal colonic tissue with distorted architecture. Growths of normal colonic tissue with distorted architecture.
Hamartomatous
solitary lesions
Polyp type via chromosomal instability pathway with mutations in APC and KRAS.
Adenomatous
Adenomatous: Tubular or villous more malignant potential?
villous
Premalignant polyp via CpG hypermethylation phenotype pathway with microsatellite instability and mutations in BRAF.
Serrated
non-neoplastic polyps
Hyperplastic
Hamartomatous
“Saw-tooth” pattern of crypts on biopsy polyp type
Serrated
Polyps cz. sporadic CRC.
Serrated