Kidney-tubule issues &Nephritic/Nephrotic Dzs. Flashcards
Fanconi Syndroma MOA
increased excretion of glucose and other substances in PCT
“Fanconi is First”
Bartter Syndrome MOA
Like Loops
Gitelman Syndrome MOA
Like Thiazide
G after B (alphabetic)
Liddle Syndrome MOA
Like Hyper-Aldo. but without any Aldosterone in systm
Liddle Syndrome Tx.
Amiloride
K+-sparing diuretic use?
Hyper-Aldo. =Conn Syndrome
Syndrome of Apparent Mineralocorticoid Excess MOA
Enzyme that converts cortisol to cortisone is defective–>cortisol can act like Aldo.!
SAME Tx.
Give steroids so body stops making cortisol
Eating what causes SAME dz.
Licorice–also inhibits enzyme that converts cortisol to cortisone
Renin/Aldo. level in Liddle syndrom?
Low both
RTA Type 4 due to:
Hypo-Aldo. –>hyper-K+
RTA Type 1 due to:
intercalated cells can’t secrete H+ (even though in DCT)
RTA Type 2 due to:
Can’t reabsorb Bicarb. in PCT
RTA associated with AI Dzs.
RTA Type 1
2 Conditions associated with RTA Type 4
- SLE
2. SCD
RTA associated with high urine pH?
RTA Type 1 (odd one)
RTA associated with hyper-K+?
Type 4
RTA associated with stones?
RTA Type 1=odd one
RTA associated with hyper-Ca2+?
RTA Type 1=odd one
4 Nephritic Syndromes (Mnemonic)
“RAAS”
Rapidly Progressive
IgA nephro-pathy (Berger)
Strep
5 Nephrotic Syndromes
- Focal Segmental GlomeruloSclerosis
- MCD
- Membranous
- Amyloidosis
- Diabetic glomerulonephropathy
- Nephritic & Nephrotic mixed syndromes
- Diffuse Proliferative GlomeruloNephritis
2. MembranoProliferative GlomeruloNephritis
Membranous glomerular disease indicates
thicken glomerular BM
Proliferative glomerular disease indicates
more cells of glomeruli
What is a primary glomerular dz.?
MCD
Nephritic syndrome MOA?
GBM damage
=Inflammatory process
Nephrotic syndrome MOA?
podocyte (charge barrier) disruption–direct or from systemic dz.