POLYCYSTIC OVARIAN SYNDROME

Question 1

What is a common endocrine disorder of unknown pathophysiology affecting up to 10% of women of reproductive age?

Answer 1

Polycystic ovarian syndrome

Question 2

PCOS is characterized by what?

Answer 2

1. Anovulation
2. Polycystic ovaries
3. Hyperandrogenism

Question 3

These are some clinical findings associated with what common endocrine disorder?

1. Menstrual disorders
2. Infertility
3. Hirsutism
4. Obesity
5. Acne
6. Insulin resistance, DM2, metabolic syndrome
7. Dyslipidemia
8. Perinatal complications if able to become pregnant

Answer 3

PCOS

Question 4

In what endocrine disorder will the LH/FSH ratio be abnormal (typically 2:1 to 3:1, normal is 1:1)?

This abnormality disrupts ovulation

Answer 4

PCOS

Question 5

True or False

You would perform this lab for PCOS

Free testosterone and sex hormone binding globulin (SHBG) if clinical evidence of hyperandrogenism is present

Answer 5

True

Question 6

True or False

You would perform this lab for PCOS

Midnight salivary cortisol or dexamethasone suppression test if clinical evidence of Cushing Syndrome is present

Answer 6

True

Question 7

True or False

In obese patients with polycystic ovarian syndrome, weight reduction and exercise are often effective in reversing the metabolic effects and in inducing ovulation.

Answer 7

True

Question 8

True or False

PCOS

metformin is used if fasting glucose is in impaired/diabetic range

Answer 8

True

Question 9

Are Combined Oral Contraceptives an effective treatment against PCOS?

Answer 9

Yes, if contraindicated consider spironolactone