Polyarteritis Nodosa Flashcards
What infection might predispose PAN?
Hep B
What is the typical age range of PAN?
40-60
What type of inflammation occurs in PAN?
Necrotising
What is the pathology of PAN?
Necrotising inflammation of small/medium arteries
How is PAN different from microscopic polyangitis?
MPAN = glomerulonephritis (rapidly progressive)
+pANCA
Main symptoms of PAN?
Ulcers
Rash
Fever
Myalgia + arthralgia
What are the ulcers like in PAN?
Punched out
Investigations?
Bloods
- FBC
- Complement
- Hep B antigen
- Autoantibody
What are the findings on FBC?
Normocytic anaemia
Raised WCC
Thrombocytosis
What are the complement results?
Low
What HBV antigens should be tested for?
HbsAg
HbeAg
What autoantibodies should be tested for
Rule out lupus
- Anti-dsDNA
- ANA
- Anti-smith
- Anti-cardiolipin
Rule out microscopic polyangitis without need for renal biopsy
- pANCA
Treatment of PAN?
Hep B treatment
- Peg Interferon
- Lamivudine
Disease modifying
- Prednisolone
- Methylprednisolone
- DMARDs
