Paget's Disease of Bone Flashcards
1
Q
Aetiology of pagets disease?
A
Familial
2
Q
What cells are affected in pagets disease?
A
Osteoclasts
3
Q
What is the pathology of pagets disease?
A
Abnormal bone repair and alteration of bone shape
4
Q
What happens when the bone shape is altered in pagets?
A
Increase in size
5
Q
What are the 3 H’s of pagets?
A
Huge
Hard
Haemorrhagic
6
Q
What are the symptoms?
A
70% asymptomatic
Other
- Pain
- Deformity
- Heat
- Neuro –> deafness
7
Q
What does pagets disease increase the risk of?
A
Osteosarcoma
Pseudofractures
8
Q
Diagnosis?
A
Bloods
X ray
9
Q
What are the levels of alkaline phosphatase, calcium, phosphate and PTH?
A
High alk phos
Normal/slightly incr. calcium and phosphate
Raised PTH
10
Q
What is shown on xray of pagetic bone?
A
Sclerosis and lysis
11
Q
Treatment?
A
Bisphosphonates
12
Q
What can be given if bisphosphonates are contraindicated?
A
Calcitonin
