Churg Srauss Syndrome and Granulomatosis with Polyangitis Flashcards
What is Churg strauss?
pANCA positive small vessel granulomatosis
Typical presentation?
Patient presents with new onset chronic rhinitis and asthma. Blood tests show eosinophilia and raised IgE.
What is the triad of symptoms in churg strauss?
Rhinitis/asthma
Eosinophilia
Glomerulonephritis
What is granulomatosis with polyangitis?
c-ANCA +ve granulomatosis
What is c-ANCA?
Antiproteinase c antibody
What is the triad of granulomatosis with polyangitis?
URTI
LRTI
Renal impairment (glomerulonephritis)
What skin finding may present with granulomatosis with polyangitis?
Pyoderma gangrenosum
What is the treatment for churg strauss and granulomatosis with polyangitis
Cyclophosphamide/azothiaprine
+ prednisolone/methylprednisolone