Poisoning Flashcards
What was BIA 10-2474 proposed for treating
- anxiety
- motor disorders associated with Parkinson’s disease
- chronic pain in people with cancer and other conditions
clinical trial of BIA 10-2474
Single doses had no serious effects
On receiving repeated higher doses, participants became extremely ill
9 groups of drugs that feature in highest proportion of poisoning substances
Many are centrally acting
- Analgesics
- Sedative/hynotics/antipsychotics
- antidepressants
- CV drugs
- Antihistamines
- Stimulants and street drugs
- Anticonvolusants
- Hormones and hormone antagonists
- Cold and cough preparations
How is paracetamol hepatotoxic
- One metabolic pathway for paracetamol produces N-acetyl-p- benzo-quinone imine (NAPQI), a reactive toxic substance
- Large doses cause hepatic necrosis due to accumulation of NAPQI
- Reducing pack sizes has had a major impact on the number of paracetamol-induced deaths
Propofol
Anaesthetic
Lorazepam (benzodiazepine)
Treats anxiety and insomnia
Midazolam
Promotes droziness and relieves anxiety
Lidocaine
Anaesthetic
Ephedrine
Low BP
Also asthma, narcolepsy and obesity
Logic behind irrigation as a decontamination method
Clears the GIT
Logic behind charcoal as a decontamination method
Forms complex with drugs preventing any more drugs from being absorbed into the bloodstream
Logic behind use of emetics as a decontamination method
Removes any drug in the stomach
In the event of poisoning, give examples of therapeutic intervention
Fluids
Intubation
Oxygen
Ventilation
What drugs can be used in the event of drug poisoning
Antiemetics
Antihistamines
Benzodiazepines
Antibiotics
Antidote & its MOA for paracetamol
N-acetylcysteine (NAC)
Neutralises the NAPQI metabolite
