Pogil questions Flashcards
What Cyclin are found during G1 Phase
Clyclin D and Cyclin E
What cyclin are found during S phase
Cyclin E and Cyclin A
What cyclin are found during G2 phase
Cyclin A, D and B
What cyclin are found during M phase
Cyclin B and D
What prevents and origin of replication from being used more than once per cell cycle?
checkpoints
List 2 events of ubiquitination and give the regulatory mechanism
Ubiquitination of cyclin : regulated by phosphate
Ubiquitination of CKI: regulated by ubiquitin
What would happen to a cell without functional retinoblastoma
Cell cycle would not be able to suppress tumorous cells as efficiently
What type of molecular sensors does a cell posses to respond to the late outcome oof the absence of functional retinoblastoma proteins
Tumor necrosis factor.
List different phases of mitosis
Prophase
metaphase
anaphase
telophase
When is the mitosis checkpoint
at the end of metaphase
What is the name of mitosis checkpoint and its role
Spindle checkpoint.
Kinetochore attachment checkpoint
Check that chromosomes are attached properly
Describe the dual roles of overlapping microtubules?
Keep the shape of the spindle.
What are the associated proteins involved in kinetechor checkpoint?
EG5, HSEF
Why do cells lacking spindle microtubules ultimately escape mitosis?
Cell can’t pull chromosomes apart
Don’t pass spindle checkpoint
Why does inhibiting microtubule induce side effects?
Because microtubules wouldn’t be able to function in regular cells.
