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Foundations of Medicine 1 > PNS Receptors and Characteristics > Flashcards

PNS Receptors and Characteristics Flashcards

1
Q

M1 receptors are located in what tissue?

A

autonomic ganglia

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2
Q

What is the response when M1 receptors are activated?

A

Depolarizes postsynaptic neurons (slow EPSP)

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3
Q

What is the mechanism of M1 receptors?

A

↑ PLC → ↑ IP3, DAG, Ca++

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4
Q

M2 receptors are located in what tissue?

A

Heart

Axon Terminals

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5
Q

What is the response when M2 receptors are activated?

A

↓ Heart rate, conduction velocity, contractility

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6
Q

What is the mechanism of M2 receptors?

A

↓ AC → ↓ cAMP; ↑ K+ channel efflux, ↓ Ca++ channel influx

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7
Q

M3 receptors are located in what tissue?

A

Smooth muscle, Secretory glands and vascular epithelium

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8
Q

What is the response when M3 receptors are activated?

A

Smooth muscle contraction
Increased secretion of secretory glands
dilates BV

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9
Q

What is the mechanism of M3 receptors in the vascular epithelium?

A

Ca++/CaM activates eNOS → ↑ NO → ↑ cGMP → relaxation

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10
Q

Nm receptors are located in what tissue?

A

Neuromuscular junctions

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11
Q

What is the response when Nm receptors are activated?

A

Skeletal muscle contraction

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12
Q

What is the mechanism of Nm receptors?

A

Opens Na+/K+ channels –> depolarization

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13
Q

Nn receptors are located in what tissue?

A

Autonomic ganglia and Adrenal medulla

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14
Q

What is the response when Nn receptors are activated?

A

Depolarization of postsynaptic neurons (autonomic ganglia)

Depolarization of medullary cells –> secretion of catecholamines (Nn)

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15
Q

What is the mechanism of Nm receptors?

A

Opens Na/K channels –> depolarization

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16
Q

What is the mechanism of M3 receptors in smooth muscle and secretory glands?

A

↑ PLC → ↑ IP3, DAG, Ca++

17
Q

A1 receptors are located in what tissue?

A

Smooth muscle and liver

18
Q

What is the response when A1 receptors are activated?

A

Contracts smooth muscle and increases glycogenolysis and gluconeogenesis (liver)

19
Q

What is the mechanism of A1 receptors?

A

↑ PLC → ↑ IP3, DAG, Ca++

20
Q

A2 receptors are located in what tissue?

A

Axon terminals
Pancreatic B cells
Vascular smooth muscle
Platelets

21
Q

What is the response when A2 receptors are activated?

A

↓ NE release (axon terminals)
↓ Insulin release (Pan B cells)
Contraction of smooth muscle
Platelet Aggregation

22
Q

What is the mechanism of A2 receptors?

A

↓ AC → ↓ cAMP; ↑ K+ channel efflux (via Gβγ); ↓ L- and N-type Ca++ channel influx; ↑ PLC → ↑ IP3, DAG, Ca++

23
Q

B1 receptors are located in what tissue?

A

Heart and Kidney

24
Q

What is the response when B1 receptors are activated?

A

↑ Heart rate, conduction velocity, contractility

↑ Renin release

25
Q

What is the mechanism of B1 receptors?

A

↑ AC → ↑ cAMP → ↑ PKA → ↑ L-type Ca++ channel influx

26
Q

B2 receptors are located in what tissue?

A

Smooth muscle
Heart
Liver and skeletal muscle
Pancreatic B cells

27
Q

What is the response when B2 receptors are activated?

A

Relaxes smooth muscle
↑ heart rate contractility
↑ glycogenolysis, gluconeogenesis (liver)
↑ insulin release

28
Q

What is the mechanism of B2 receptors?

A

↑ AC → ↑ cAMP; in smooth muscle, inhibits MLCK → ↓ myosin-PO4 → relaxation

29
Q

B3 receptors are located in what tissue?

A

Lipocytes

30
Q

What is the response when B3 receptors are activated?

A

activates lipolysis

31
Q

What is the mechanism of B3 receptors?

A

↑ AC → ↑ cAMP

32
Q

D1 receptors are located in what tissue?

A

Vascular smooth muscle (esp renal)

33
Q

What is the response when D1 receptors are activated?

A

Dilates blood vessels

34
Q

What is the mechanism of D1 receptors?

A

↑ AC → ↑ cAMP

35
Q

D2 receptors are located in what tissue?

A

axon terminals and cholinergic neurons in the gut

36
Q

What is the response when D2 receptors are activated?

A

↓ DA release

↓ GI motility

37
Q

What is the mechanism of D2 receptors?

A

↓ AC → ↓ cAMP; ↑ K+ efflux; ↓ Ca++ influx

Foundations of Medicine 1 (12 decks)

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