PNS development and Neurocristopathies Flashcards

1
Q

Central Nervous System

A

Consists of the brain and spinal cord and is protected by the cranium and verterbal column

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2
Q

Peripheral nervous system

A

Consists of all components of the nervous system outside the CNS. This includes cranial nerves and ganglie, spinal nerves and ganglie, autonomic nerves and ganglia, and the enteric nervous system (only exists in the gut).

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3
Q
A
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4
Q

What is the autonomic nervous system? How many neurons connect the pathway from spinal cord to target structues?

What are its two divisions?

A
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5
Q

Peripheral nervous system development arises from what? (2 main things)

A
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6
Q

What are the two groups of cells outside the neural tube that the PNS develops from? Which is the primary contributor?

A
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7
Q

The PNS develops in an ___ system, essentially in a ___ to ____ sequence

A

integrated; cranial; caudal

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8
Q

Neurlation is an inductive event that occurs where? and results in the formation of what? (which gives rise to what?). This can be subvidided into primary (which is what) and secondary (which is what?)

A
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9
Q

Primary neuralation occurs when? Continues through when?

A

3rd week, immediately following gastrulation. Primary neuraltion continues through the 4th week

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10
Q

In the region of the 4th - 6th pairs of somites, the ___plate, and ___groove develop on the posterior aspect of the trilaminar embryo. From the the process continues both ___ and ____

A
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11
Q

What induces the overlying ectoderm to differentiate into the neural plate? (2 things)

A
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12
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13
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14
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15
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16
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17
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18
Q

Unfused potion at the cranial and caudal ends are referred to as what?

A
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19
Q

Anterior neurospores close at what?

Posterior neurospores close at what?

A

Anterior = 24-25 days

Posterior close at 26-27 days

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20
Q

What markes the end of primary neurulation?

A

Closure of the neurospores

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21
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22
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23
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24
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25
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Dealmination of neural crest cells
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Abdominal primary tumor; asymptamatic
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Sympathetic, Horner's
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Compression
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What is the most common benign peripheral nerve tumor in adults?
Schwannoma
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Tumor of schwann cells are of what orgin?
neural crest
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Schwann cells do what, generally, in the PNS?
Form a protective lining around most of the nerves in the PNS
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Do schwannoma's metastize?
No, but can grow to impress sizes
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Where are schwannoma's commonly located near?
CN VIII (acoustic neuroma)
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If a shwannoma is located along a peripheral nerve you should expect?
Localized pain, numbness, tingling and/or muscle weakness
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Type 1
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What is this showig?
A vestibular schwannoma
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(Neurofibromatosis) Flat patches on the skin that are darker than the surrounding area. What is this? When does it appear?
Cafe-au-lait-spots appears early in childhood and increase in size and number as patient ages
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Later
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Usually located on or just under the skin, but can form larg plexiform tumors that can impact surrounding structures. What is this?
Neurofibromas (noncanerous, benign) tumors
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Appear in the iris during childhood Do not interefere with vision What is this?
Lisch nodules
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vision; vision
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suprarenal (adrenal); crest
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40-60
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epinephrine and norepinephrine
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heart rate, blood pressure, and metabolism
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Hypertension (most common symptom) Headaches, palpitations, and episodic sweating (40%)
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Pallor (pale skin) Chest and/or abdominal pain
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facial abnormalities (wide nasal bridge)
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Pigmentation; gray
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Skin; eyes blue, different
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aganglionic megacolon 1/5000
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