PMR & Crystals Flashcards

1
Q

What are the different crystal deposition diseases?

A
  • Gout
  • Pseudogout
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is gout?

A

Inflammatory crystal monoarthropathy caused by deposition of monosodium urate crystals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the presentation of gout?

A
  • Heat (calor)
  • Pain (dolor)
  • Redness (rubor)
  • Swelling (tumour)
  • The above symptoms tend to occur in the MTPJ joints in 50% of patients
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why does hyperuricaemia occur?

A

Under excretion:

  • Renal impairment
  • Lesch-Nyhan syndrome
  • Excess alcohol
  • Exercise, starvation, dehydration
  • Lead poisoning
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How is an acute attack of gout managed?

A
  • NSAID’s
  • Colchicine
  • Steroids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How is an attack of hyperuricaemia managed?

A

1st attack:

  • Not treated unless:
  • Renal insufficiency
  • Urate calculi
  • Single attack of polyarticular gout
  • Treat if 2nd attack within 1 year
  • DO NOT treat asymptomatic hyperuricaemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the signs and symptoms of polymyalgia rheumatica?

A
  • Sudden onset of shoulder +- pelvic girdle stiffness
  • ESR > 45
  • Anaemia
  • Malaise
  • Weight loss
  • Fever
  • Depression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the association between polymyalgia rheumatica (PMR) and giant cell arteritis (GCA)?

A

20% of patients with Polymyalgia Rheumatica may have GCA

50% of patients with GCA may have PMR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How is PMR managed?

A
  • Prednisolone 15mg/day for 18-24 months
  • Bone prophylaxis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which joint is most commonly affected in gout?

A

Metatarsophalangeal joint of the foot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How is gout investigated?

A

Serum urate

FBC

WCC

U&E’s

Creatinine

GFR

Polarized light microscopy of synovial fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the difference between gout and pseudogout?

A

Pseudogout:

  • Knee most commonly affected
  • Calcium pyrophosphate

Gout:

  • 1st MTPJ
  • Sodium urate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What other condition is associated with PMR and GCA?

A

High ESR Anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly