Pleuromutilins Flashcards
1
Q
Mode of action
A
50S protein synthesis- bacteriostatic
2
Q
Cross resistance with:
A
macrolides and phenicols
3
Q
Pharmacokinetics
A
Absortion: Excellent oral
Distribution: Excellent
Metabolism: Liver- CYP450 inhibition!! THINK when use other medicines. incr toxicity
Excretion: bile and urine
4
Q
Toxicity
A
Low, but can maybe cause vulvar edema from urine, skin erythema.
5
Q
Spectrum:
A
Gram+, fastidious, Brachyspira, Lawsonia (intracellular), Mycoplasma (no cell wall)
6
Q
Indication:
A
Swine dysentery, proliferative enteropathy, mycoplasmosis, respiratory tract inf.- pig and poultry
7
Q
Drugs:
A
Tiamulin- inj and oral
Valnermulin- oral
ONLY to food producing animals!
