Beta lactamase inhibitors

Question 1

What does Monobactams work on?

Answer 1

Gr-, Pseudomonas

Question 2

Name the monobatams (drug names and admin.)

Answer 2

Aztreonam- parenteral, Tigemonam- oral

Question 3

What do we treat with monbactams?

Answer 3

Septicemia, meningitis, perotinitis, E.Coli multiresistant UTI.
Use only when others don’t work- CIA!

Question 4

Name the carbapenems:

Answer 4

Imipenem (+cilstatin), Meropenem

Question 5

What do we treat with carbapenems?

Answer 5

Last resort antimicrobial!! Highly active against all important known pathogenic bacteria.

Question 6

Meropenem use:

Answer 6

septicemia, parental use

Question 7

Imipenem metabolism

Answer 7

Metabolised by dihydropeptidase in kidney. Short halflife ca 1-2 h. Cilstatin inhibits the enzyme, and T1/2 increase to 8 h.

Question 8

Betalactamase inhibitors + what drugs do they protect:

Answer 8

Clavulenic acid (+amoxicilln) =suicide inhibitor
Sulbactam (+ampicillin)
Tazobactam (+piperacillin)

Question 9

Betalactamase activity is found in these bacteria:

Answer 9

Gr+: Staphylococcus

Gr-: E.coli, salmonella, klebsiella, proteus, bacteriodes, haemophilus, pasteurella, bordetella, PSEUDOMONAS