Lincosamides

Question 1

Mode and mechanism of action:

Answer 1

50S, inhibition of protein synthesis. Bacteriostatic.

Question 2

Cross reaction:

Answer 2

Macrolides and phenicol

Question 3

Pharmacokinetics:

Answer 3

Absorption: good
Distribution: good- bones and IC. BM infection S. aureus, osteomyelitis
Metabolism: Liver -> bile -> dysbacteriosis
Excretion: bile and urine (BUT not suitable use for UTI)

Question 4

Toxicity

Answer 4

severe tissue irritation, dysbacteriosis- use probiotics! STOP treatment if diarrhea- can be lethal!!

Question 5

Spectrum

Answer 5

Gram+
ANAEROBIC also- foot rot, oral cavity, bite wound

NOT fastidious- not for respiratory tract inf!

Brachyspira hyodysenteriae, Lawsonia intracellularis, Mycoplasma, Campylobacter

Question 6

Drug names:

Answer 6

Lincomycin, Clindamycin

Question 7

Lincomycin:

Answer 7

For food producers. Foot rot, mastitis, metritis, bite wound, swine dysentery, proliferative eneteropathy,

mycoplasmosis= lincomycin+ spectinomycin= good for respiratory.

Question 8

Clindamycin:

Answer 8

Favourite of dentists.
More active, mainly companion animals. 
Oral cavity, gram + and gram-
Abcess, dermatitis- stap/strept =gram+
gram-= oral cavity, osteomyelitis, anal sacculitis- dog
ORAL
SE: dysbacteriosis and vomiting

Question 9

Forbidden?

Answer 9

Horse and herbivore rodents