Platinum Agents. Flashcards
1
Q
What is the mode of action of platinum agents?
A
Heavy metals that bind
to DNA leading to cross
links in strands.
2
Q
What are the 2 platinum agents?
A
Cisplatin.
Carboplatin.
3
Q
What are the platinum agents used to treat?
A
Osteosarcomas.
Carcinomas.
4
Q
Which drug causes fatal pulmonary oedema in cats?
A
Cisplatin.
5
Q
What are the 3 unique side effects of cisplatin?
A
Acute vomiting.
Renal toxicity.
Neurotoxicity.
6
Q
What are the 2 unique side effects of carboplatin?
A
Delayed neutropenia and thrombocytopenia.
