Alkylating Agents. Flashcards
What is the MOA of alkylating agents?
They alkylate DNA.
What are the 4 alkylating agents?
Cyclophosphamide.
Chlorambucil.
Melphalan.
Lomustine.
What are the 2 indications for cyclophosphamide?
Lymphoma.
Metronomic chemotherapy.
Which alkylating agent causes sterile hemorrhagic cystitis?
Cyclophosphamide.
What drug can we replace cyclophosphamide with if sterile hemorrhagic cystitis occurs?
Chlorambucil.
What is melphalan used to treat?
Multiple myeloma.
What is a unique side effect of melphalan?
BM stem cells are affected.
What is lomustine used to treat?
Lymphoma.
Mast cell tumors.
Brain tumors.
Why is unique about the distribution of lomustine?
It is lipophilic and crosses the blood brain barrier.
How long does it take for bone marrow toxicity to occur following administration of lomustine?
It has delayed toxicity (10-14 days).
Which alkylating agent causes liver toxicity in dogs?
Lomustine.
