Antimetabolites. Flashcards
1
Q
What is the MOA of antimetabolites?
A
They interfere with
DNA synthesis.
2
Q
What are the 3 antimetabolites?
A
5-fluorouracil.
Cytosine arabinoside.
Rabacfosadine.
3
Q
What is 5-fluorouracil used to treat?
A
Carcinomas.
4
Q
What 2 things is cytosine arabinoside used to treat?
A
Myelogenous leukemias.
Granulomatous mengioencephalitis.
5
Q
What is rabacfosadine used to treat?
A
Canine lymphoma.
6
Q
Which antimetabolite causes fatal neurotoxicities in cats?
A
5-fluorouracil.
7
Q
What is unique about the distribution of cytosine arabinoside?
A
It crosses blood brain barrier.
8
Q
Why do we have to administer cytosine arabinoside multiple times a day?
A
It has a very short half-life.
9
Q
What are the 2 side effects of rabacfosadine?
A
Pulmonary fibrosis.
Cutaneous reaction.
