Antitumor Antibiotics. Flashcards
1
Q
What is the MOA of antitumor
antibiotics?
A
They inhibit topoisomerase II.
2
Q
What are the 2 antitumor
antibiotics?
A
Doxorubicin (Adriamycin).
Mitoxantrone (Novantrone).
3
Q
What 3 things is doxorubicinn used to treat?
A
Lymphoma.
Sarcomas.
Carcinomas.
4
Q
What is the most common side effect of doxorubicin?
A
GI effects.
5
Q
What are 3 unique side effects of doxorubicin?
A
Cardiotoxicity.
Mast cell degranulation.
Severe vesicant.
6
Q
What IS a unique side effect of doxorubicin in cats?
A
Renal toxicity.
7
Q
What drug is used as a replacement for doxorubicin intreating carcinomas?
A
Mitoxantrone.
8
Q
Mitoxantrone should not be combined with what drug?
A
Piroxicam as it is nephrotoxic.
