Platelets Flashcards
At what level does severe thrombocytopenia occur?
< 50,000 Platelets
What are the presenting symptoms of thrombocytopenia?
Excessive/repetitive bleeding
Excessive bruising
Bleeding at unusual sites
Excess mucosal bleeding
Petechiae
How is disseminated intravascular coagulation (DIC) classified?
Acute or Chronic
What are common triggers of acute DIC?
Sepsis, trauma (life threatening, mortality rate 40-80%)
What is the primary treatment of DIC?
Treat underlying disorder
Hemodynamic stabilization +/- ventilation
Whole blood transfusions
What are the risk factors for thrombotic thrombocytopenia purpura (TTP)
African ancestry, obesity, certain HLA subtypes
Unlike other bleeding disorders, TTP will present with what system involvements?
Will often have renal, GI and CNS involvement
What is the average platelet count in TTP?
20,000 (severe)
What is the treatment for hereditary TTP?
Plasma infusion
What is the treatment for acquired TTP?
TPE - therapeutic plasma exchange
Shiggela Toxin usually causes which type of bleeding disorder in children?
Hemolytic-Uremic Syndrome (HUS)
What is the prodrome symptom of hemolytic-uremic syndrome?
bloody diarrhea
What is the treatment for hemolytic-uremic syndrome?
Supportive care
PRBC as needed, platelet transfusion, fluid resuscitation, correction of electrolyte disturbances
What viruses are associated with immune thrombocytopenia purpura (ITP)?
Hepatitis C and HIV
In kids, does acute ITP typically resolve?
Yes, and on it’s own
