platelets Flashcards
platelets promote vasoconstriction by producing …………. that helps in hemostasis
serotonin
how does platelets contribute to blood coagulation?
by releasing platelet factor 4 and clotting factor 5 &11
platelets, as well as macrophages and endothelial cells, help in growth of vascular endothelium(wound healing) by secreting ……….?
platelet-derived growth factor
………………… aid to prevent adherence of platelets to the normal
vascular endothelium.
However, ………………….. help in adhesion and aggregation of
platelets.
Glycoproteins
glycoprotein receptors
At the site of injury,
………….. release the vasoconstrictors serotonin and thromboxane A2.
Then
The clotting protein thrombin stimulates ……………… to secrete the potent vasoconstrictor endothelin-1.
Platelets
Endothelial cells
The bleeding time is related to ……
Primary hemostasis
……………. Binds to glycoprotein receptors on platelets and acts as a bridge connecting platelets and sites of injured epithelium
von Willebrand factor (vWF)
Heparin+Antithrombin3 bind together to work as ….
Anticoagulants
They inhibit factor 10 and thrombin
…………. inhibits coagulation by binding to thrombin.
Thrombomodulin inhibits coagulation by binding to thrombin.
Protein C and S act together to inactivate activated factors ………….and ……… to cause ……….
V and VIll
(Inactivates inhibitor of tissue plasminogen activator (anticoagulant))
Lyses of fibrin
Plasminogen and plasmin function in ………………
+
Tissue plasminogen activator function in ……..
Dissolves fibrin and fibrinogen
+
Activates plasminogen
The intrinsic and extrinsic pathways converge at the common pathway for
coagulation, which begins with the activation of factor ……..
X
The …………. pathway is triggered when blood contacts a negatively charged surface (e.g., exposed subendothelial collagen; aggregations of platelets).
Intrinsic
The …………. pathway is activated when blood contacts cells outside the vascular endothelium
Extrinsic
