PLASMA REGULATORY PROTEINS FOR COMPLEMENT Flashcards

includes DEFICIENCY OF COMPLEMENT REGULATORS

1
Q

dissociates C1r and C1s from C1q

A

C1 INHIBITOR (C1 INH)

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2
Q

cleaves C3b and C4b

A

FACTOR I

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3
Q

cofactor with I to INACTIVATE C3b, prevents binding of B to C3b

A

FACTOR H

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4
Q

acts as a cofactor with I to inactivate C4b

A

C4-BINDING PROTEIN

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5
Q

the principal soluble regulator of the ALTERNATIVE PATHWAY

A

FACTOR H

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6
Q

prevents attachment of the C5b67 complex to cell membrane

A

S PROTEIN (VITRONECTIN)

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7
Q
A
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8
Q

dissociates C2b or Bb from binding sites, thus preventing formation of c3 convertase

A

DAF (DECAY ACCELERATING FACTOR)

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9
Q

DAF is associated with what CD number?

A

CD 55

DAF, daghan F…FIFTY-FIVE

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10
Q

PREVENTS INSERTION OF C9 into cell membrane

A

MIRL

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11
Q

MIRL is associated with what CD number?

A

CD 59

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12
Q

cofactor with I; mediates transport of immune complexes; it is found MAINLY ON PERIPHERAL BLOOD CELLS

A

CR1

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13
Q

it binds C3b and C4b but has the GREATEST AFFINITY FOR C3b

A

CR1

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14
Q

found on virtually all epithelial and endothelial cells EXCEPT ERYTHROCYTES

A

MCP

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15
Q

it is THE MOST EFFICIENT COFACTOR FOR FACTOR I-MEDIATED CLEAVAGE OF C3b

A

MCP

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16
Q

MOST COMMON DEFICIENCY

A

C2

dagha’g C2 na drink sa grocery so common siya 🤩

17
Q

MOST SEVERE DEFICIENCY

A

C3

18
Q

related MAINLY with Neisseria infections

A

C5-C8

19
Q

NO KNOWN DISEASE ASSOCIATION

A

C9

20
Q

associated with intravascular or extravascular hemolysis because of COMPLEMENT ACTIVATION; assoc with PNH

A

DAF and MIRL

21
Q

PNH is caused by a mutation of what gene?

A

PIG-A GENE

PHOSPHATIDYL INOSITOL GLYCAN A

22
Q

associated with HEREDITARY ANGIOEDEMA

A

C1 INH DEFICIENCY

23
Q

associated with RECURRENT PYOGENIC INFECTIONS; C3 will be constantly turn over to be activated until it becomes depleted

A

FACTOR H and FACTOR I DEFICIENCY