PATHOLOGY AND ANTIBODIES OF AUTOIMMUNE DISORDERS Flashcards

1
Q

selective destruction of the insulin producing B cells of the islets of Langerhans in the pancreas

A

TYPE 1 DM

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2
Q

unregulated secretion of T3 and T4 due to stimulation of TSH receptor by antibody

A

GRAVE’S DISEASE

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3
Q

destruction of the thyroid gland

A

HASHIMOTO’S THYROIDITIS

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4
Q

destruction of the parietal cells of the stomach mucosa leading to intrinsic factor deficiency

A

PERNICIOUS ANEMIA

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5
Q

an immune-mediated inflammatory disease that attacks myelinated axons in the CNS, destroying the myelin and the axon in variable degrees and producing significant physical disability

A

MULTIPLE SCLEROSIS

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6
Q

combination of glomerulonephritis with alveolar hemorrhage and ANTI-GBM antibodies

A

GOODPASTURE’S SYNDROME

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7
Q

cholestatic liver disease characterized by a BREAKDOWN OF IMMUNE TOLERANCE TO MITOCHONDRIAL and NUCLEAR Ags causing injury to the biliary epithelial cells lining the small intrahepatic bile ducts

A

PRIMARY BILIARY CIRRHOSIS

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8
Q

liver disease that is characterized by DIFFUSE PARENCHYMAL INFLAMMATION AND HEPATIC CELL NECROSIS

A

CHRONIC ACTIVE HEPATITIS

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9
Q

disease of the NEUROMUSCULAR JUNCTION (NMJ) caused by Abs that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle

A

MYASTHENIA GRAVIS

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10
Q

granuloma formation; “pauci-immune” vasculitis and glomerulonephritis are the histologic hallmarks

A

WEGENER’S GRANULOMATOSIS

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11
Q

keratoconjunctivitis sicca (dryness of eyes) and xerostomia (dry mouth) due to lymphocytic infiltrates

A

SJOGREN’S SYNDROME

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12
Q

involves the HARDENING and TIGHTENING OF THE SKIN AND CONNECTIVE TISSUE

A

SCLERODERMA

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13
Q

ANTI-CENTRIOLE, ANTI-Scl

A

SLCERODERMA

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14
Q

ANTI-SSA, ANTI-SSB

A

SJOGREN’S SYNDROME

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15
Q

ANTI-NEUTROPHILIC CYTOPLASMIC MEMBRANE (ANCA)

A

WEGENER’S GRANULOMATOSIS

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16
Q

ANTI-ACETYLCHOLINESTERASE

A

MYASTHENIA GRAVIS

17
Q

ANTI-SMOOTH MUSCLE Ab

A

CHRONIC ACTIVE HEPATITIS

18
Q

ANTI-MITOCHONDRIAL

A

PRIMARY BILIARY CIRRHOSIS

19
Q

ANTI-GLOMERULAR BASEMEMENT MEMBRANE Ab

A

GOODPASTURE’S SYNDROME

20
Q

ANTI-MYELIN SHEATH

A

MULTIPLE SCLEROSIS

21
Q

ANTI-PARIETAL CELL, ANTI-INTRINSIC FACTOR

A

PERNICIOUS ANEMIA

22
Q
  1. ANTI-THYROID PEROXIDASE
  2. ANTI-THYROGLOBULIN Ab
  3. ANTI-MICROSOMAL Ab
A

HASHIMOTO’S THYROIDITIS

23
Q
  1. ANTI-TSH RECEPTOR Ab
  2. ANTI-THYROID PEROXIDASE
  3. ANTI-THYROGLOBULIN Ab
A

GRAVE’S DISEASE

24
Q
  1. ANTI-GLUTAMIC ACID DECARBOXYLASE (GAD)
  2. ANTI-INSULIN Ab