PATHOLOGY AND ANTIBODIES OF AUTOIMMUNE DISORDERS Flashcards
selective destruction of the insulin producing B cells of the islets of Langerhans in the pancreas
TYPE 1 DM
unregulated secretion of T3 and T4 due to stimulation of TSH receptor by antibody
GRAVE’S DISEASE
destruction of the thyroid gland
HASHIMOTO’S THYROIDITIS
destruction of the parietal cells of the stomach mucosa leading to intrinsic factor deficiency
PERNICIOUS ANEMIA
an immune-mediated inflammatory disease that attacks myelinated axons in the CNS, destroying the myelin and the axon in variable degrees and producing significant physical disability
MULTIPLE SCLEROSIS
combination of glomerulonephritis with alveolar hemorrhage and ANTI-GBM antibodies
GOODPASTURE’S SYNDROME
cholestatic liver disease characterized by a BREAKDOWN OF IMMUNE TOLERANCE TO MITOCHONDRIAL and NUCLEAR Ags causing injury to the biliary epithelial cells lining the small intrahepatic bile ducts
PRIMARY BILIARY CIRRHOSIS
liver disease that is characterized by DIFFUSE PARENCHYMAL INFLAMMATION AND HEPATIC CELL NECROSIS
CHRONIC ACTIVE HEPATITIS
disease of the NEUROMUSCULAR JUNCTION (NMJ) caused by Abs that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle
MYASTHENIA GRAVIS
granuloma formation; “pauci-immune” vasculitis and glomerulonephritis are the histologic hallmarks
WEGENER’S GRANULOMATOSIS
keratoconjunctivitis sicca (dryness of eyes) and xerostomia (dry mouth) due to lymphocytic infiltrates
SJOGREN’S SYNDROME
involves the HARDENING and TIGHTENING OF THE SKIN AND CONNECTIVE TISSUE
SCLERODERMA
ANTI-CENTRIOLE, ANTI-Scl
SLCERODERMA
ANTI-SSA, ANTI-SSB
SJOGREN’S SYNDROME
ANTI-NEUTROPHILIC CYTOPLASMIC MEMBRANE (ANCA)
WEGENER’S GRANULOMATOSIS
ANTI-ACETYLCHOLINESTERASE
MYASTHENIA GRAVIS
ANTI-SMOOTH MUSCLE Ab
CHRONIC ACTIVE HEPATITIS
ANTI-MITOCHONDRIAL
PRIMARY BILIARY CIRRHOSIS
ANTI-GLOMERULAR BASEMEMENT MEMBRANE Ab
GOODPASTURE’S SYNDROME
ANTI-MYELIN SHEATH
MULTIPLE SCLEROSIS
ANTI-PARIETAL CELL, ANTI-INTRINSIC FACTOR
PERNICIOUS ANEMIA
- ANTI-THYROID PEROXIDASE
- ANTI-THYROGLOBULIN Ab
- ANTI-MICROSOMAL Ab
HASHIMOTO’S THYROIDITIS
- ANTI-TSH RECEPTOR Ab
- ANTI-THYROID PEROXIDASE
- ANTI-THYROGLOBULIN Ab
GRAVE’S DISEASE
- ANTI-GLUTAMIC ACID DECARBOXYLASE (GAD)
- ANTI-INSULIN Ab
TYPE 1 DM
