Plasma composition and red cell metabolism

Question 1

Defect in RBC cytoskeletal proteins?

Answer 1

Hereditary spherocytosis

Question 2

Why do people get ascites in cirrhosis?

Answer 2

Reduced protein (albumin) in the blood creates lower oncotic pressure so fluid leaves blood for tissue.

Question 3

What causes the O2 saturation curve to shift to the right (decreased Hb-O2 affinity)?

Answer 3

H+ increases

P-CO2 increase

Temp increases

BPG increase

Question 4

What causes O2 saturation curve to shift left (increased Hb-O2 affinity)?

Answer 4

H+ decrease

P-CO2 decrease

Temp decrease

Question 5

What causes acquired methemoglobinemia?

Answer 5

benzocain

Question 6

What is methemoglobinemia?

Answer 6

Fe3+ iron bound to hgb instead of Fe2+

• caused by reactive oxygen species oxidizing the Fe2+ after it has bound
• Cytochrome b5 reduces the Fe3+ of methemoglobin

Question 7

Why is G6PD deficiency bad for RBCs?

Answer 7

Can’t reduce NADP to NADPH which then can’t reduce glutathione.

Need glutathione to turn ROS to H2O so cell doesn’t lyse.