Antineoplastics Flashcards
Reversibly inhibits 26S proteasome → activation of signaling cascades, cell-cycle arrest, & apoptosis
CCS: G2-M
Side fx: Reactivation of VZV (prophylactic acyclovir) and Hep B (possible fulminant hepatic failure)
Bortezomib
Selectively inhibits secretion of proinflammatory cytokines (ex: tumor necrosis factoralpha); enhances cell-
mediated immunity by stimulating proliferation of antiCD3 stimulated T cells; inhibits trophic signals to angiogenic factors in cells. Inhibits the growth of myeloma cells by inducing cell cycle arrest and cell death. Decreases VEGF.
Side fx: Myelofibrosis, ALL, Hodgkins, B-cell lymphoma, neutropenia, thrombocytopenia, peripheral neuropathy
Lenalinomide/thalidomide
Promotes T-cell proliferation
Cell cycle non-specific
*narrow therapeutic window, lots of side fx (general malaise, fever)
IL-2
Alkylating agent (new for this course), cross links DNA
CCNS
SIDE FX: bone marrow supression
Melphalan
Inhibits purine synthesis/utilization and immunosuppressant (inhibits humoral response)
-target PNP and PRPP
CSS: S phase
side fx: bone marrow suppression
6-mercaptopurine
Synthetic glucocorticoid, anti-inflammatory, alters transcription, induction of cell death in immature lymphocytes
CCNS
side fx: Immunosuppression
Prednisone/predisolone
Drug from previous course:
Inhibits nucleotide synthesis
Folate
Methotrexate
Drug from previous course:
Inhibits nucleotide synthesis
Purine (uracil?) analog
5-fluorouracil
Drug from previous course:
Inhibits DNA synthesizing enzymes
Pyrimidines
Ara-C
Drug from previous course:
Inhibits DNA synthesizing enzymes
Purines
Fludarabine
Drug from previous course:
Alkylating agents
Name 4 of them
Busulfan
Cyclophosphomide
Temozolamide
Carmustine
Drug from previous course:
Crosslinks DNA
Platinum
Cisplatin
Drug from previous course:
Intercalates DNA
Doxorubicin
Drug from previous course:
Creates strand breaks
Topo II inhibitor
Etoposide
Drug from previous course:
Interrupts mitosis by increasing spindle formation
Paclitaxel
