Plague Flashcards

1
Q

the 3 plague pandemics

A

justinian plague, “Black Death” in china, and 1860s modern china

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2
Q

yersinia pestis

A

transmitted by fleas; zoonosis of wild rodents

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3
Q

select agent category a:

A

pose a risk to national security, easily disseminated or transmitted, high mortality rate

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4
Q

yersinia pestis transmission

A

normal reservoir in wild rodents; a flea that’s infected could bit the rodent or spread through fluids and then infect the rodent; the infected flea bites a rat, then it either dies of infects another flea that then infects a human

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5
Q

___ can be infected

A

dogs and cats

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6
Q

only need ___ cells to infect

A

10

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7
Q

can get septicemic plague from ___

A

bubonic plague

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8
Q

sylvatic

A

enzootic, endemic in rodent populations, still endemic in the US

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9
Q

bubonic

A

swelling of the lymph nodes, cells eventually enter the blood stream, most common

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10
Q

pneumonic

A

lungs

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11
Q

septicemic

A

blood

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12
Q

bubonic symptoms

A

swelling of the lymph nodes, gangrene, death can occur in <2 weeks

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13
Q

bubonic incubation period

A

2-6 days

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14
Q

pneumonic symptoms

A

coughing, chest pain, hypotension, 100% mortality if not treated

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15
Q

pneumonic incubation period

A

1-3 days

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16
Q

septicemic symptoms

A

seizures, enlarged liver and spleen, delirium, patient may die before symptoms occur

17
Q

septicemic incubation period

A

no defined incubation period

18
Q

plague diagnosis

A

multiple stains of bacterium, anti-FI serology test, PCR

19
Q

plague treatment

A

antibiotics, supportive care

20
Q

virulence factors

A

biofilm formation, Yops, others

21
Q

Yops

A

forms a secretion system

22
Q

Yop B/C

A

forms pores in host membrane

23
Q

other Tops

A

function inside the host cell cytoplasm; limits phagocytosis; limits cell signaling for innate immune signaling

24
Q

plague cases have ___ overall

A

decreased