Measles Flashcards
measles was eliminated in the United States in ___, but almost lost its elimination status in ___
2000; 2019
measles is ___ since it is found in other countries
not eradicated
new measles cases are from ___ and usually ___
travel; resolve themselves
lose elimination status after ___
one year
measles virus
1 negative strand of RNA
2 membrane proteins important for pathogenesis
F-fusion and H-hemagglutinin
inactivated easily by ___
heat, sunlight, acidic pH, ether
the H-hemagglutinin binds to the ___ and then the F-fusion will insert into the ___
receptor; membrane
transmission
only in humans; resides in the nose and throat mucus; coughing and sneezing; inhale directly or touch surface; no animal reservoir;
infectious for ___ hours in airspace
2
___ will become infected if not immune
90%
incubation period
7-14 days
sypmtoms
high fever, couch, runny nose, red and watery eyes, Koplik spots inside the mouth, rash, flat red spots on face at hairline, spread down to the rest of body, fever spikes again
contagious
4 days before and 4 days after rash appears
pathogenesis of measles
entry infection of local lymph nodes, systemic dissemination, prodromal, symptomatic, recovery, immune suppression
