PK/PD Flashcards
What is pharmacokinetics?
What the body does to a drug.
Order of PK in drug administered by i.v bolus
- Distribution, 2. Metabolism, 3. Excretion
Order of PK in per os (p.o) administration
LADME (1. Liberation, 2. Absorption, 3. Distribution, 4. Metabolism, 5. Excretion)
In non-compartmental analysis t(max) is…
Time to max conc
In non-compartmental analysis C(max) is…
Max conc
AUC
Area under the (concentrion-time) curve
MEC
Minimal effective conc
MTC
Max therapeutic conc
TI
Therapeutic index - MTC/MEC
Define bioavailability
Fraction of an administered dose of unchanged (not metabolised) drug that reaches the systemic circulation.
Factors influencing PK parameter
Liberation, absortion, distribution, metabolism, excretion
What is pharmacodynamics?
What the drug does to the body.
Factors influencing PD parameters
Mutation at target site, Co-medication
PK describes…
Concentration-time profile of a drug
PD describes…
Concentration-effect profile of a drug
For PK/PD modelling malaria need to know…
- Initial parasite number (P), 2. Parasite growth rate (a), 3. Effect of patient immunity f(I), 4. Effect of drug f(C)
Parasite PD variation
Max effect (kill rate) V(max); Half max inhibitory effect IC(50); Slope (n)
Parasite PK variation
Absorption rate; V of distribution; Clearance rate
Hysteresis of plasma drug conc vs response (clockwise and anticlockwise)
C: Rapid tolerance against drug arises
A: Drug has to be distributed to its site of action
