PK 4

Question 1

What does k12 mean?

Answer 1

rate of transfer from central component to tissue component

central –> tissue

Question 2

What does k21 mean?

Answer 2

rate of transfer from tissue component to central component

tissue –> central

Question 3

What does K10 represent?

Answer 3

elimination from the central compartment

Question 4

What does it mean if K12 > K21 ?

Answer 4

tissue compartment will have much more drug than the central compartment

Question 5

What does it mean if K21 > K12 ?

Answer 5

central compartment will have much more drug than the tissue compartment

Question 6

What is a three compartment open model?

Answer 6

it also involves deep tissue

*we won’t be calculating questions on this

Question 7

What does the number of compartments or exponentials depend on?

Answer 7

1) route of administration
2) rate of absorption
3) total time for sampling
4) number of samples during collection period
5) assay

Question 8

First line = line __

Answer 8

B

Question 9

Residual line = line __

Answer 9

A

Question 10

What does B mean?

Answer 10

Cp0 of line B

Question 11

What does b mean?

Answer 11

K of line B

Question 12

What does A mean?

Answer 12

Cp0 of line A

Question 13

What does a mean?

Answer 13

K of line A