PK 2 Flashcards
1
Q
If the concentration points go continuously down, what type of dosage form is it?
A
IV
2
Q
If the concentration points go up and then go down, what type of dosage form is it?
A
Oral
3
Q
If you are assuming it is given IV and performing AUC, what must you find first?
A
Do regression analysis to find Cp0 = the concentration at time zero
4
Q
What does “extrapolate to infinity” mean?
A
- first find your AUC
- then find K
Extrapolate to infinity = AUC + Cfinal/K
5
Q
What is the formula for relative availability?
*not on formula sheet
A
[AUC a/dose a]/[AUC b/dose b]
6
Q
What is the formula for relative availability of urinary excretion data?
A
Du(infinity)a / Du(infinity)b
Du(infinity) = total amount in urine
7
Q
What is the formula for Absolute availability?
A
[AUC po/dose po] / [AUC iv/dose iv]
