Multiple Dose Regimens

Question 1

What does dosage regimen depend on?

Answer 1

• strength

- frequency of drug administration

Question 2

What are plasma drug concentration predictions based on?

Answer 2

pharmacokinetic parameters obtained

Question 3

What does a single dose depend on?

Answer 3

• strength

- dosage interval (tau)

Question 4

What is the principle of superposition?

Answer 4

• independent of early doses
• assume first order kinetics
• kinetics of the first dose, do not affect the next dose, and so on
• see chart on slide 2

Question 5

What does R mean here?

Answer 5

index of drug accumulation

Question 6

R (index of drug accumulation) is independent of ____

Answer 6

dose

Question 7

How many half-lives to reach 99% eliminated?

Answer 7

6.6

• have this memorized
• from slide 5

Question 8

What is the formula for # of doses to reach 99% steady state?

Answer 8

(6.6 x T1/2) / tau

Question 9

What is the formula for the time for Cav?

Answer 9

6.6 x T1/2

Question 10

What does tau equal?

Answer 10

dosage interval

Question 11

DL = ?

Answer 11

loading dose

Question 12

D0 = ?

Answer 12

maintenance dose

Question 13

Dose ratio = ?

Answer 13

DL / D0

Question 14

When dose the dose ratio = 2?

Answer 14

when Tau = T1/2

Question 15

What are some advantages of determination of bioequivalence?

Answer 15

1) patient acts as own control
2) Cmin is maintained
3) assay is more accurate

Question 16

What are some disadvantages of determination of bioequivalence?

Answer 16

1) takes longer time to complete study

2) need more samples