pituitary adrenal disorders

Question 1

clinical signs of hyperA

Answer 1

increased ado fat deposition, panting, hepatomegaly and abdo distension, testicular atrophy, increased vulval size, muscle weakness and atrophy, altered mentation, dermal changes

Question 2

describe dermal change sin hyperA

Answer 2

hyperkaratosis, flaky skin, comedones, symmetrical alopecia, hyper pigmentation, calcinosis cutis, recurrent infections or infestations

Question 3

clin path for hyperA

Answer 3

increased thrombocyte count, eosinopaenia, lymphocytopaenia, hypercholesterolaemia, increased ALP, low USG?

Question 4

how to dx hyperA

Answer 4

stress leukogram, basal urinary corticoid excretion, dynamic tests - low dose dex suppression test, ACTH stim test to dx ADH/PDH, US adrenals

Question 5

tx for PD hyperA

Answer 5

sx = bilateral adrenalectomy and tx as hypoA
mx = TRILOSTANE, MITOTANE induction and maintenance phases on protocol: reduce cortisol production through adrenocorticolysis

Question 6

tx for AD hyperA

Answer 6

mx = trilostane - inhibits cortisol synthesis, can induce hypoA d/t increased blood flow and haemorrhage

Question 7

characteristics of adrenal gland dz in ferrets

Answer 7

like hyperA but no increased cortisol - normal pit gland, marked adrenomegaly, usually unilateral, can be bi, seen in middle aged to older ferrets

Question 8

clinical signs of adrenal gland dz in ferrets

Answer 8

pruritus, symmetrical alopecia, usually starts in the spring, can see urethral obstruction in hobs, vulval enlargement

Question 9

dx of adrenal gland dz in ferrets

Answer 9

radiographs usually, abdo US, serum hormone estimations elevated in 1 or more

Question 10

tx of adrenal gland dz in ferrets

Answer 10

sx removal, ketoconazole trilostane, mitotane

Question 11

prevention of adrenal gland dz in ferrets

Answer 11

more common the younger they are neutered, try GnRH implants instead - DESLORIN