equine endocrinopathies Flashcards

1
Q

pathophysiology of PPID

A

loss of DA inhibition, melanotropes hypertrophy = overproduction of B-endorphin, a-MSH, CLIP and modest increase in ACTH, Can compress local areas too

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2
Q

early clinical sign of PPID

A

laminitis, decreased performance, regional hypertrichosis, delayed shedding, wieght loss w regional adiposity, change in attitude/lethargy

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3
Q

advanced clinical signs of PPID

A

lethargy, neuro defecits/blind, hyperglycaemia, muscle atrophy, rounded abdo, laminitis, hyperhydrosis, PU/PD, no shedding, recurrent infections

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4
Q

dx of PPID

A

hormone assays - basal ACTH conc (may not detect early), insulin dysregulation tests, dynamic tests - TRH stim test

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5
Q

mx tx of PPID

A

DA agonist, cortisol antagonists, 5-HT agonist

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6
Q

prognosis for PPID

A

animals can live for a long time, laminitis tends to be limiting factor, tx for life!

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7
Q

signs of EMS

A

obesity, regional adiposity, insulin dysreg, hyperTGaemia, hypertension, pro-inflam state, altered adipokines

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8
Q

dx of EMS

A

detect insulin dysfunction - dynamic test = combined glucose-insulin test, oral glucose test, oral sugar test

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9
Q

tx of EMS

A

wieght reduction, exercise, drugs - thyroxine (increases metabolic rate until weight lost), also can try supplements and nutraceutical

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