Pit phys and pharm Flashcards
What is another name for growth hormone?
Somatotropin
- Gs thus increase in cAMP
What is another name for growth hormone inhibiting hormone GHIH?
Somatostatin
- Gi
What is another name for insulin like growth factor-1 IGF-1?
Somatomedin
What are the only two releasing hormones or axises that have inhibitors hormones?
Growth hormone axis
Prolactin axis
Other than GHIH what else inhibits the release directly of Growth Hormone?
Dopamine
- Remember that Druggies are skinny
What does Gh cause the release of from the liver?
IGF-1
What does somatostatin bind to? Affects?
SSTR-1 through SSTR-5
- Gi
- Decrease cAMP through K+ channels
What is Growth hormone binding protein?
Mutated growth hormone receptor that gets release from plasma membrane
What second messenger goes GH use?
Jak/Stat
What minerals does GH cause to be retained?
phosphorus
Nitrogen
Potassium
What does GH do to your blood sugars?
Hyperglycermic
- Diabetogenic
How is GH diabetogenic?
Reduces tissue uptake of glucose
Increase liver production of glucose
What does severe def in GH of kids lead to?
Proportional dwarfism
- Short stature
What is Laron Syndrome?
AR disease which is defective receptor with insensitivity to GH
What are some other causes of short stature?
Turner's SHOX Poor nutrition Stress Disproportional dwarfism
When is the max release of GH
2 hours after onset of deep sleep
- teens need this for growth
What is Sermorelin?
GHRH analog and arginine combined
What is the argninie/GHRH test?
Does the pit produce normal amounts of GH
- IGF-1 baseline
- Inject Arginine
- Inject GHRH
- Serum Gh every 15 for an hour
What are the interpretations of the arginine/GHRH test?
greater than 8ng/ml is normal
what do we monitor when we give rhGH?
IGF-1 levels
What are some AE’s of using rhGH?
Antibodies
Scoliosis of rapid growth
diabetogenic
Why would we need rhIGF?
for people not responding to GH
- like pts with Laron syndrom
What is Mecasermin (Increlex)?
rhIGF-1
What is Mecasermin rinfabate (Iplex)?
rhIGF-1 + IGFB3
- which is just its binding protein
- these arent as affective as rhGH
