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HRM > Pit phys and pharm > Flashcards

Pit phys and pharm Flashcards

1
Q

What is another name for growth hormone?

A

Somatotropin

- Gs thus increase in cAMP

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2
Q

What is another name for growth hormone inhibiting hormone GHIH?

A

Somatostatin

- Gi

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3
Q

What is another name for insulin like growth factor-1 IGF-1?

A

Somatomedin

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4
Q

What are the only two releasing hormones or axises that have inhibitors hormones?

A

Growth hormone axis

Prolactin axis

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5
Q

Other than GHIH what else inhibits the release directly of Growth Hormone?

A

Dopamine

- Remember that Druggies are skinny

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6
Q

What does Gh cause the release of from the liver?

A

IGF-1

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7
Q

What does somatostatin bind to? Affects?

A

SSTR-1 through SSTR-5

  • Gi
  • Decrease cAMP through K+ channels
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8
Q

What is Growth hormone binding protein?

A

Mutated growth hormone receptor that gets release from plasma membrane

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9
Q

What second messenger goes GH use?

A

Jak/Stat

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10
Q

What minerals does GH cause to be retained?

A

phosphorus
Nitrogen
Potassium

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11
Q

What does GH do to your blood sugars?

A

Hyperglycermic

- Diabetogenic

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12
Q

How is GH diabetogenic?

A

Reduces tissue uptake of glucose

Increase liver production of glucose

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13
Q

What does severe def in GH of kids lead to?

A

Proportional dwarfism

- Short stature

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14
Q

What is Laron Syndrome?

A

AR disease which is defective receptor with insensitivity to GH

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15
Q

What are some other causes of short stature?

A 
Turner's
SHOX
Poor nutrition
Stress
Disproportional dwarfism
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16
Q

When is the max release of GH

A

2 hours after onset of deep sleep

- teens need this for growth

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17
Q

What is Sermorelin?

A

GHRH analog and arginine combined

18
Q

What is the argninie/GHRH test?

A

Does the pit produce normal amounts of GH

  1. IGF-1 baseline
  2. Inject Arginine
  3. Inject GHRH
  4. Serum Gh every 15 for an hour
19
Q

What are the interpretations of the arginine/GHRH test?

A

greater than 8ng/ml is normal

20
Q

what do we monitor when we give rhGH?

A

IGF-1 levels

21
Q

What are some AE’s of using rhGH?

A

Antibodies
Scoliosis of rapid growth
diabetogenic

22
Q

Why would we need rhIGF?

A

for people not responding to GH

- like pts with Laron syndrom

23
Q

What is Mecasermin (Increlex)?

A

rhIGF-1

24
Q

What is Mecasermin rinfabate (Iplex)?

A

rhIGF-1 + IGFB3

  • which is just its binding protein
  • these arent as affective as rhGH
25
Q

What are the Ae’s of rhIGF-1?

A

Increase p450

Hypoglycemia

26
Q

What cause acromegaly or gigantism?

A

Pit adenoma which secretes GH

27
Q

What is the indication for GH hypersecretion?

A

Elevated IGF-1

28
Q

How do we treat Gh hypersecretion?

A

Dope and Somatostatin analogs

- these tumors express high amount of these receptors

29
Q

What of octreotide?

A

Somatostatin analog which is a long acting

30
Q

What is Pegvisomant?

A

Polyethylene glycol PEG derivative of a mutant GH

- only binds to one GH receptor which leads to no downstream events

31
Q

What are the dopamine agonists?

A

Bromocriptine and Cabergoline

  • high affinity for D2
  • Ergot derivatives
32
Q

What causes the release of Prolactin?

A
  1. Prolactin releasing hormone
  2. VIP
  3. Thyrotropin releasing hormone
33
Q

What inhibits the release of prolactin?

A

Dopamine

34
Q

Increase in prolactin has what physiologic affects?

A

Breast dev
Milk secretion
Involved in immunity and auto-immunity

35
Q

What inhibits milk secretion/

A

High levels of progesterone?

36
Q

How is prolactin regulated?

A

It is under tonic inhibition from the hypothalamus by dopamine

37
Q

What is the difference between the long and short receptors for prolactin?

A

Long is action

- short soaks up extra prolactin but has no downstream affects

38
Q

If infundibulum is severed what would the hormones look like?

A

Prolactin increased

Everything else decreased

39
Q

What does increase in prolactin do to GnRH?

A

inhibits it

40
Q

How do we treat hypersecretion of prolactin?

A

Cabergoline

- dope agonist

HRM (6 decks)

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