Antineoplastic hormones

Question 1

What can we treat Prostate cancer with?

Answer 1

GnRH agonists
GnRH Antagonists
5 Alpha reductase inhibitors
Testosterone receptor antagonists

Question 2

What can we treat breast cancer with?

Answer 2

GnRH Agonists and Antagonists
Estrogen receptor modifiers
Estrogen receptor disrupters
Aromatase inhibitors

Question 3

What is the MOA of Goserelin and Leuprolide?

Answer 3

GnRH receptor agonists

• first increase LH and FSH then decrease
• need to continuously give then you can desensitize system

Question 4

What is the MOA of Degarelix?

Answer 4

GnRH receptor antagonist

Question 5

What is the MOA of Fiasteride and dutasteride?

Answer 5

5 alpha reductase inhibitors

- inhibit the conversion of testosterone to dihydrotestosterone

Question 6

What is the MOA of Abiraterone acetate?

Answer 6

17 alpha hydroxylase inhibitor

- which inhibits the production of testosterone

Question 7

What are the androgen receptor antagonists? What is another name for them?

Answer 7

Bicalutamide
FLutamide
Nilautamide

chemical castrators

Question 8

What is a classic treatment regimen for prostate cancer?

Answer 8

Goserelin or leuprolide with combination of anti-androgen to cover you for initial increase in FSH and LH

Question 9

What is the MOA of AMinoglutethimide?

Answer 9

blocks pregnenolone synthesis

Question 10

What are the aromatase inhibitors? inhibit?

Answer 10

Anastrazole
Letrozol
Exemestane

• inhibit conversion of peripheral androgens to estrogen

Question 11

what is the significance of exemestane?

Answer 11

IRREVERSIBLY inhibits aromatase

Question 12

What are the selective estrogen receptor downregulators SERDs?

Answer 12

Fluvestrant

• inhibits all estrogen receptor actions and causes ER degradation
• also blocks trophic actions of estrogens on breast

Question 13

What are the SERMs?

Answer 13

Selective estrogen receptor modulators

1. Tamoxifen
2. Rlaxifene
3. Tormifene