Pistun

Question 1

Perfusion limited vs. diffusion limited

Answer 1

Perfusion: If the partial pressure of the gas in the plasma equilibrates with the alveolar partial pressure in the amount of time the blood is passing through the capillary.
Diffusion: If equilibration does not occur in time
— Perfusion limited is completely normal and if you think about it, during exercise you can increase RBC transit time to abut 2.5 because blood is pumping faster and you can get more O2 in the blood. On the contrary though, being diffusion limited is pathological a. Means there is an issue with one of the variables we discussed earlier or something else.

Question 2

What factors determine rate of diffusion of a gas?

Answer 2

Proportional: Surface area, diffusivity, partial pressure across barrier
Inversely proportional: thickness of the barrier

Also, the Ebook said that it is inversely proportional to the molecular weight of the gas.

Question 3

In what form will you find most of the O2 in our body?

Answer 3

Bound to Hb.

- However, a small amount is physically dissolved in the blood and it is this O2 that is measured for partial pressure.

Question 4

What is the O2 dissociation curve?

Answer 4

The percentage of O2 bound to Hb divided by the O2 carrying capacity of Hb.

Question 5

What are come factors that lead to moving The O2 dissociation curve to the right/unloading more O2?

Answer 5

High Temperature, low pH, high 2,3-BPG, high CO2

Question 6

What factors within the tissues allow for unloading of O2?

Answer 6

Within the tissues, we have lower pH, higher temp, and more CO2.

Question 7

How is CO2 carried in the blood?

Answer 7

80% Is in The form of HCO3
10% in the form of CO2 in plasma
10% in the form of CO2 attached to carbamino AAs.

Question 8

What. Is the Haldane effect??

Answer 8

Now we are looking at the CO2 dissociation curve. When you are in areas where Hb is not bound to O2 like in the tissues, the Hb is more likely to be bound to CO2 or pick up CO2, so the shift will be to the left. If however you are in areas where you have high percentage of Hb bound to O2, then the CO2 dissociation curve will be shifted to the right and it will readily give up CO2 and not pick up any.

Question 9

Bohr effect

Answer 9

O2 dissociation curve moves to the right in more acidic environments.

Question 10

What is the maximum carrying capacity of one grab of Hb? What do we actually see?

Answer 10

1.39 mL of O2. We actually see about 1.34 mL due to some that is bound to methemoglobin and CO.