Physiology of Taste and Smell Flashcards

1
Q

What are branchial arches?

A

The branchial arches are embryologic structures that develop into anatomic structures in the adult human.

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2
Q

What structures of the tongue arise from the first branchial arch of the endoderm?

A
  • Tuberculum impar (midline) and lateral lingual swellings.
  • Form the mucosal surface of the anterior 2/3rds of the tongue
  • Trigeminal nerve for touch and pain
  • Facial nerve for taste
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3
Q

What structures of tongue arise from 3rd branchial arch of endoderm?

A
  • Cupula
  • Posterior 1/3rd of tongue
  • Glossopharyngeal nerve
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4
Q

What structures of tongue arise from mesoderm in upper neck?

A
  • Intrinsic and extrinsic muscles

- Hypoglossal nerve

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5
Q

What is the role of the fingiform papillae?

A

Carry taste buds

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6
Q

What is the role of the filiform papillae?

A

Rough surface for manipulation of food.

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7
Q

How many taste buds do we have?

A

2000-8000 to detect substances dissolved in saliva.

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8
Q

What are the 5 primary tastes?

A
  • Sour (acid, H+)
  • Salty (Na+)
  • Sweet (glucose)
  • Bitter (cofee, beer)
  • Savoury/umami (glutamate)
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9
Q

Why is biterness so sensitive?

A

It is a protective function towards poisons

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10
Q

What structures and cranial nerves are present in the anteroir 2/3rds of the tounge?

A
  • Lingual nerve (Trigeminal, CN V)

- Chorda tympani (facial nerve CN VII)

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11
Q

What cranial nerve is found in the posterior 1/3rd of the tounge?

A

-Glossopharyngeal nerve (CN IX)

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12
Q

Where do taste fibres synapse and then what happens to them?

A

In solitary muscles of medulla.

They then run up to gustatory cortex and the thalamus also plays a role.

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13
Q

What are other sensory inputs that contribute to taste and some examples and also where these inputs are mediated?

A
  • Pungency (chilli)- pain and temp. receptors
  • Coolness (menthol)- temp. receptors
  • Fattiness - specific fat taste or respnose to creamy texture?
  • Temperature - enhances release of odorants to nose, imporves texture
  • Texture (crunchy crisps, creamy foods)
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14
Q

What are some clinical defects that can affect taste?

A

-Ear surgery can cause damage to the chorda tympani
Unilateral has minimal symptoms
Bilateral gives unpleasant metallic taste in mouth
-Dry mouth affects taste
-Surgery to submandibular and sublingual salivary glands could damage lingual nerve:
-unilateral; loss of taste and loss of common sensation in floor of mouth and tounge

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15
Q

What contributes to flavour?

A

Mostly due to smell

Sight, memory, mood, expectation and context can also affect this

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16
Q

What is the structure of the nose?

A
  • Horizontal structure (7cm long)
  • Olfactory mucosa sits just belowcribriform plate, olfactory bulbs just above
  • Consists of septum, middle turbinate, inferior turbinate
17
Q

What is one of the basic functions of the nose?

A

Warms and humidifies incoming air.

18
Q

Compare quiet breathing and sniffing?

A
  • Quiet = laminar airflow over the inferior turbinate

- Sniff = turbulence to mix the air and send odorants to the roof of the nose

19
Q

Describe the action of olfactory receptors?

A
  • Odorant molecules in the air dissolve in nasal mucus
  • Detected by rhodopsin like detectors on dendrites of olfactory cells
  • Each receptor responds to more than one odorant
  • Each odorant stimulates more than one receptor
  • The combination of this provides the response
  • Detection threshold varies
20
Q

What does the detection threshold of olfactory receptors depend on?

A

-On solubility, pH and no. of receptors

21
Q

Where does the olfactory nerve project to?

A
  • Amygdala
  • Hippocampus
  • Parahippocampal gyrus
  • The only sensory modality that doesnt relay primarily to the thalamus
22
Q

What is a clinical defect that can result from nose dysfunction and what can cause it?

A

-Congenital anosmia; can have seroius causes such as base of skull fracture, neuro disorders, brain tumour, kallmans syndrome, COVID.

23
Q

What problems does anosmia lead to?

A
  • Cant appreciate food
  • Risks to health (smoke alarm, gas appliances, sell by dates)
  • Impact on quality of life (physocological, many become suicidal).