Physiology final- digestive system Flashcards
4 processes of the digestive system
motility, secretion, digestion and absorption
Muscularis Externa
major smooth muscle that lines digestive tract. circular inner layer and longitudinal outer layer.
digestive muscles
innervated by the vagus nerve and the parasympathetic nervous system.
Gastric Emptying
factors in the stomach: amount of chyme in stomach influences strength of contraction. Factors in Duodenum: fat, acid, hypertonicity, and distension (too much stuff in stomach)
Chief Cells
produce pepsinogen and when activated begin protein digestion
Parietal Cells
secrete HCl
Gastric mucosal Barrier
enables stomach to contain acid without injuring itself
Pancreatic secretion is regulated by
CCK (regulates gall bladder contraction) and secretin
Secretin
stimulates secretion of bicarbonate in response to low stomach pH/acidic levels.
CCK
Digests fat and protein. signals the gall bladder to contract. negative feedback loop for satiety, tells you to stop eating.
liver
largest and most metabolic organ in the body. makes and secretes bile salts
gall bladder
sits under the liver. release of bile comes from cck. common bile duct takes bile from the gall bladder to the lumen of the small intestine.
hepatic portal vein
takes drained blood from the digestive tract to the liver for processing and storage of absorbed nutrients. blood also then leaves the liver through the hepatic portal vein back to the heart. fat doesn’t go to the liver for absorption
Bile
made by hepatocytes, stored and concentrated in the gall bladder. made up of bile salts, cholesterol, lecithin and bilirubin
Bile salts
derivatives of cholesterol to break up fats into smaller molecules. function as detergents. 95% of bile salts are reabsorbed by the terminal ileum.
Liver functions not related to digestion
makes bile, detoxifying or degrading body wastes, synthesizes plasma proteins, stores glycogen, removes bacteria and worn out rbc’s
brush-border enzymes
fixed on microvilli in the small intestine. activate enzymes that break down proteins and carbs. not secreted into the lumen.
small intestine
almost all absorption occurs here. brush-border enzymes are here
tripsinogen
made in the pancreas and is activated by brush-border enzymes to make active tripsin.
digestion and absorption of carbs
carbs break down lactose, maltose and sucrose into monosaccharides. secondary active transport by sodium is used to move glucose from lumen into the capillary venous space.
digestion and absorption of fats
bile salts coat fat droplets. pancreatic lipase breaks fats down into monoglycerides and fatty acids stored in micelles. monoglycerides and fatty acids then move out of micelles. monoglycerides and fatty acids move in through diffusion and cholesterol is transported into the cell. everything is added back together in the cell and make chylomicrons and moved to the lymphatic system to make lacteal.
Gastrin (G cells)
stomach cells, stimulate parietal cells
zymogens
inactive, secreted by the pancreas into the lumen of the small intestine to be activated. includes tripsinogen.